Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Skin hyperpigmentation
ADR ID BADD_A04040
ADR Hierarchy
23      Skin and subcutaneous tissue disorders
23.05      Pigmentation disorders
23.05.01      Hyperpigmentation disorders
23.05.01.003      Skin hyperpigmentation
Description A disorder characterized by darkening of the skin due to excessive melanin deposition. [CTCAE] Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance. [MeSH]
MedDRA Code 10040865
MeSH ID D017495
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hyperpigmentation skin | Skin hyperpigmentation | Hypermelanosis | Hyperpigmentation | Hypermelanoses
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Uroporphyrinogen decarboxylaseP06132Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01136Imatinib0.001332%
BADD_D01137Imatinib mesylate--
BADD_D01139Imipramine--
BADD_D01142Imiquimod0.002317%
BADD_D01150Indinavir--
BADD_D01151Indinavir sulfate--
BADD_D01204Isoniazid0.012741%
BADD_D01213Isotretinoin0.001894%
BADD_D01222Ixabepilone--
BADD_D01239Lactic acid--
BADD_D01241Lamisil--
BADD_D01243Lamotrigine0.001160%
BADD_D01250Lasofoxifene--
BADD_D01252Leflunomide0.003098%
BADD_D01253Lenalidomide0.015054%
BADD_D01265Levetiracetam--
BADD_D01275Levofloxacin0.000347%
BADD_D01281Levonorgestrel0.010423%
BADD_D01309Lomefloxacin--
BADD_D01310Lomefloxacin hydrochloride--
BADD_D01359Mechlorethamine0.003996%
BADD_D01360Mechlorethamine hydrochloride--
BADD_D01366Medroxyprogesterone acetate0.000511%
BADD_D01392Mercaptopurine--
BADD_D01401Metformin--
BADD_D01418Methotrexate0.001400%
BADD_D01420Methoxsalen--
BADD_D01424Methyl aminolevulinate hydrochloride--
BADD_D01431Methylphenidate--
BADD_D01433Methylprednisolone--
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